临床主攻颅脑创伤💃🏻、脑血管病的微创手术治疗以及神经重症患者的抢救与康复🛄。
科研上主要致力于颅脑损伤治疗新策略的探索和研究，研究的主要方向为颅脑创伤后中枢神经细胞间的Crosstalk对神经功能的保护作用💥。作为第一负责人主持国家自然科学基金面上项目（2项）、上海市科委（1项）🧄、上海市浦东新区民生项目（2项）及江西省教育厅重点项目（1项）等多项课题的研究🛴。
2015入选上海市 “浦东新区优秀青年医学人才”、2020年入选江西省“杰出青年基金”等多项人才培养计划
Dr. Chen’s clinical expertise focus is on the minimally invasive surgical treatment of TBI, cerebrovascular disease and the rescue of patients with severe neurological diseases.
In scientific research, he is mainly devoted to the exploration of new strategies for the treatment for TBI, and the main direction of this research is the protective effect of Crosstalk between central nerve cells on neurological function after TBI. He is also a recipient of numerous research and investigation grants (including in charge of 2 grants from the National Natural Science Foundation).
Dr. Chen won the " Excellent Young Medical Talents Project of Pudong New Area" in 2015 and " Outstanding Youth Project of Jiangxi Province" in 2020
发表的文章(List of Articles) 以独立第一及共一作者所发表的文章(As First Author)
1.Zou SF#, Chen W#, Ding H#, Duan J*, Jiang BX*, Feng JG*, et al. Involvement of autophagy in the protective effects of ginsenoside Rb1 in a rat model of traumatic brain injury. Eur J Drug Metab Ph. 2022; 47(6):869-877.
2.He B#, Chen W#, Zheng P, et al. Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding mir-195 in traumatic brain injury. Aging-US. 2021; 13(6):8127-8145.（中科院分区：2区）
3.Chen W, Hong T, Feng JG, et al. Astrocytes-derived exosomes induce neuronal recovery after traumatic brain injury via delivering GJA1-20k. J Tissue Eng Regen Med. 2020; 14(3):412-423.（中科院分区：2区）
4.Chen W#, He B#, Zheng P, et al. Astrocytic insulin-like growth factor-1 protect neurons against excitotoxicity. Front Cell Neurosci. 2019.:298. （中科院分区：2区）
5.Chen W, Zhao L, Liu N, et al. Elevated expression of mir-302 cluster improves TBI by inhibiting phosphorylation of Cx43 via ERK signaling. J Chem Neuroanat. 2019; 99:1-8.
6.He B#, Chen W#, Zheng P, et al. Micro-326 decreases tau phosphorylation and neuron apoptosis through inhibition of JNK signaling pathway by targeting VAV1 in Alzheimer,s disease. J Cell Physiol. 2020; 235(1): 480-493. （中科院分区：2区）
7.Chen W#, He B#, Zheng P. Astrocytic IGF-1 prevents excitotoxic downregulation of ADAR1 in calcium dynamics. J Cell Biochem. 2019; 120(6):9097-9103.
8.Chen W, Zheng P, Feng JG, et al. Upregulation of connexin43 is critical for irradiation induced neuroinflammation. CNS＆ Neurol Disorder-DR. 2018; 17(7):539-546.
9.Chen W, Guo YJ, Tong WS, et al. Phosphorylation of connexin 43 induced by traumatic brain injury promotes exosome release. J Neurophysiol. 2018; 119(1):305-311.
10.Chen W, Guo YJ, Tong WS, et al. Cx40 correated with oxidative stress in brains of TBI rats. Restor Neurol Neurosci. 2017; 35(2):217-224.
11.Chen W, Feng JG, Tong WS. Phosphorylation of astrocytic Cx43 by ERK1/2 impairs BBB in acute cerebral ischemia. Cell Biosci. 2017; 7.:43. （中科院分区🫸🏿：2区）
12.Chen W, Guo YJ, Tong WS, et al. Involvement of autophagy in Cx40 reduction in late phase of TBI in rats. Brain Res Bull. 2017; 131:100-106.
13.Chen W, Guo YJ, Tong WS, et al. Involvement of Cx40 in the protective effects of ginsenoside Rb1 against TBI. Cell Mol Neurobiol. 2016; 36(7):1057-1065. （中科院分区🏺：2区）
14.Chen W, Guo YJ, Tong WS, et al. Protective effect of ginsenoside Rb1 on integrity of BBB following cerebral ischemia. Exp Brain Res. 2015; 233(10):2823-2831.
以通讯/共通讯作者发表的文章(As Corresponding Author)
1. Zheng P#, Feng JG#, Zou SF*, Chen W*, et al. Neonatal microglia and proteinase inhibitors-treated adult microglia improve traumatic brain injury in rats by resolving the neuroinflammation. Bioeng Transl Med. 2022; 7(1):e10249. （当年度中科院分区📕：1区/TOP期刊，IF:10.684）
2. Feng JG#, Zou SF#, Chen W*, et al. Astrocyte-derived exosome-transported GJA1-20k attenuates traumatic brain injury induced cognitive impairments in rats.Chin Med J（Engl）. 2023; 136(7):880-882.（中科院分区：2区，卓越/三高T1期刊❓🤽🏻♂️， IF:6.13 ,PMID:36728924）
3. Ren DB#, Zheng P#, Zou SF#, Feng JG*, Zhong CL*, Chen W*, et al.GJA1-20k enhances mitochondria transfer from astrocytes to neurons via Cx43-TnTs after traumatic brain injury. Cell Mol Neurobiol. 2022; 42(6):1887-1895.（中科院分区：2区）
4.Ren DB#, Zheng P#, Feng JG#, Zou SF*, Hong T*, Chen W*, et al. Overexpression of astrocytes-specific GJA1-20k enhances the viability and recovery of the neurons in a rat model of traumatic brain injury. ACS Chem Neurosci. 2020; 11(11):1643-1650. （中科院分区：2区）
5.Zheng P, He B, Chen W*. Inhibition of micro-RNA103a inhibits the activation of astrocytes in hippocampus tissues and improves the pathological injury of neurons of epilepsy rats by regulation BDNF. Cancer Cell Int. 2019.:109.
